Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis

Corneal endothelial integrity in aging mice lacking superoxide dismutase-1 and/or superoxide dismutase-3

PURPOSE To evaluate the age-induced changes in corneal endothelial morphology in mice lacking the cytosolic copper-zinc superoxide dismutase (SOD-1), the interstitial extracellular superoxide dismutase (SOD-3), or both of these SOD isoenzymes. METHODS The central corneal endothelial morphologies of old C57BL-6J wild type (n=19), SOD-1 null (n=16), SOD-3 null (n=15), and SOD1/3 null (n=11) mic...

Superoxide dismutase Superoxide dismutase

disease osteoarthritis progression and end - stage Superoxide dismutase downregulation in

http://ard.bmj.com/content/early/2010/05/25/ard.2009.119966.full.html Updated information and services can be found at: These include: References http://ard.bmj.com/content/early/2010/05/25/ard.2009.119966.full.html#ref-list-1 This article cites 43 articles, 9 of which can be accessed free at: P<P Published online May 28, 2010 in advance of the print journal. service Email alerting box at the t...

Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase.

Oxidative damage caused by reactive oxygen species (ROS) has been proposed to be critically involved in several pathological manifestations of aging, including cognitive dysfunction. ROS, including superoxide, are generally considered as neurotoxic molecules whose effects can be alleviated by antioxidant enzymes. However, ROS also are known to be necessary components of the signal transduction ...

The role of manganese superoxide dismutase in skin aging

The free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan. The skin represents an excellent and accessible model organ to study aging that is characterized by atrophy, wrinkle formation, reduced tensile strength and impaired wound healing. Oxidative stress as a consequence of an imbalance in prooxidant...